Seth and Richie seek help from Santánico; Freddie and Ximena have an encounter with Brasa.
Five months ago, Kate breaks out of a psychiatric institution, while there, she identifies herself as a entity named 'Amaru'. In Waco, Texas, Gonzalez and Ximena investigate a trail of culebra attacks who lead themselves to a confrontation with Brasa. The Gecko brothers look for Santanico in hopes to persuade culebras to join them in the fight against the demons; she is revealed to be running a underground fight ring in Piedras Negras; she is implied to be in a relationship with a woman named Manola and initially rejects the brothers' offer, then Seth is forced into a match, Amaru and another demon named Olmeca arrive and get themselves into a fight with the brothers and Santanico; Manola is killed by Amaru and Olmeca is killed by Santanico; Santanico finally agrees to depart with the brothers again. Amaru finds a concert ad for Scott and orders Brasa to find him.
- Various Culebras-head ripped off/various; killed by Olmeca
- Manola Jimenez-soul burned; killed by Amaru
- Olmeca-impaled through the head; killed by Santanico Pandemonium
- Head Games and this episode aired as a two-episode premiere on September 6, 2016.
- La Reina means "The Queen" in Spanish. The title can refer to Santanico or Amaru, since they are the queens of their respective communities.