The Fuller Family is a religion based family and originates from Texas.
- (Film) Fullers-The Fullers suffered a tragedy before the start of the first film and they are on vacation to get away. They consist of Jacob, Kate and Scott. They are eventually kidnapped by the Gecko brothers and they head across Mexico at the Titty Twister. Everyone in the bar is attacked by the vampires and they are very few survivors. Jacob is bitten by Sex Machine and later meets a mercy killing by Scott. Scott is being torn to pieces by the vampires when Kate finishes him and the vampires, leaving her the only member of the family to survive.
- (TV) Fullers-Jacob, Kate and Scott are on the road taking a "vacation", and it is later revealed that Jacob is fleeing because of the death of his wife, Jennifer. They are later involved with the Geckos, who hold them hostage, and they drive them across the Mexican border to the Titty Twister. They are one of the few survivors besides the Geckos, Aiden and Freddie. Scott is turned into a culebra by Carlos and Kate is taken to an altar by Aiden. Before he can sacrifice her, Freddie saves her and Jacob is turned by Scott, as he wants his family with him. Jacob then tells Kate to kill him as he doesn't want to become one and she mercy kills him while he is starting to turn. Three months afterwards, Scott is at the Twister and Kate with Seth. Scott partners with Carlos is trying to take over the empire and after Carlos shoots Kate, Scott declares vengeance and beheads Carlos for killing Kate. Later on, Kate is then resurrected by the Santa Sangre.
- Jacob Fuller (Film)-He was a pastor who's wife Jennifer had been killed in a car accident prior to the start of the film. He and his children are on a vacation and they happen to go to the same motel that Seth and Richie Gecko are at. They are taken hostage by the brothers and they will remain safe until they cross the border and cut their deal. While at the bar, it's revealed that many of employees are vampires and Jacob, his family, the Geckos and two other survivors are the only ones left from the massacre. Jacob is bitten by Sex Machine and begins to slowly turn into a vampire. He bites Scott, but is later killed by him.
- Jennifer Fuller (Film)-Jenny is the wife of Jacob and the mother of Kate and Scott who was killed in a car accident, before the start of the film.
- Kate Fuller (Film)-Katherine is the daughter of Jacob and his wife Jennifer, and the adopted sister of Scott. She is with her family on vacation and they eventually come across the Gecko brothers at the Dew Drop Motel. After they cross the Mexican border and go into the Titty Twister, the family, the Geckos and other bar goers are attacked by the vampires in the bar. Kate is eventually the only member of the Fuller family to survive and make it out of the bar alongside Seth Gecko. She asks him if he wants company, but he tells her no and she goes into her family RV.
- Scott Fuller (Film)-Scott is the adopted son of Jacob and Jennifer and younger brother of Kate. He is on vacation with his family in Texas and they end up getting kidnapped by the Geckos, Richie and Seth. They get to the Titty Twister and Scott, his family, Seth, Sex Machine and Frost are the only survivors left. Scott and Kate make a promise to Jacob that they will kill him once he becomes a vampire. Scott fights with his family and Seth, and after Jacob turns, Scott kills him. Scott is then attacked by a group of vampires and asks Kate to finish him and the vampires off. She shoots them and besides killing the vampires, Scott is killed as well.
- Jacob Fuller (TV) (?-2014)-Jacob was a pastor at a Bethel church and was married to Jennifer. He was a indirect cause to her car accident and decided to leave the church and Bethel with his children. The family eventually comes across the Gecko brothers and are kidnapped by them. They cross the Mexican border and into a bar called the Titty Twister. He eventually is mercy killed by Kate when he is bitten in the arm by Scott.
- Jennifer Fuller (?-2014)-She was the wife of Jacob and the mother of Kate, while being the adopted mother of Scott. Sometime before the start of the series, Jennifer had been suicidal and had wanted to die. One night, she and Jacob were on the road and she tried to take control of the steering, but this ended becoming an accident and she died from her injuries.
- Kate Fuller (TV) (1990s-)-Katherine currently known as Kate, is the daughter of Jacob and Jennifer, and the adopted older sister of Scott. She, her father and brother are on a "vacation" and she finds out about her mother's car accident and how her father was involved. She later mercy kills her father when he asks her to kill him as he was turning into a culebra and promises that she will help Scott. She partners up with Seth Gecko for some months and later tries to help Scott out. She asks for the assistance of Freddie and then joins up with her brother and Carlos in finding the Santa Sangre. This ends up leading her to being shot by Carlos and eventually dies from her wounds. Kate is then resurrected by the Santa Sangre and becomes possessed by Amaru. After Amaru is defeated, Kate joins up with Seth and Richie robbing banks.
- Scott Fuller (TV) (1990s)-)-JianJun, currently known as Scott, is the adopted son of Jacob and Jennifer, and the younger adopted brother of Kate. According to Kate, he always had a dangerous streak to him and was kind of wary of him. He takes a "vacation" with Kate and Jacob, and this eventually leads him into being turned into a culebra by Carlos. After three months, he and Carlos try to find the Santa Sangre and this eventually leads to Carlos shooting Kate, angering Scott and leaving him vowing for vengeance. He decapitates Carlos to avenge Kate's death. After defeating Amaru, Scott goes off on his own.
- Fuller is an English occupational name for a dresser of cloth, coming from the Old English "fullere" and the Latin "fullo", with the addition of the English agent suffix.